Cyclin D1 anticorps (AA 65-245)

N° du produit ABIN7113141

Cet anticorps anti-Cyclin D1 est un anticorps Souris Monoclonal détectant Cyclin D1 dans WB et ELISA. Adapté pour Humain et Souris.

Aperçu rapide pour Cyclin D1 anticorps (AA 65-245) (ABIN7113141)

Antigène: Cyclin D1 (CCND1)

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Cyclin D1 est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 8E8

Détail du produit anti-Cyclin D1 anticorps

Épitope: AA 65-245

Fonction: CCND1 antibody

Purification: Protein A+G purification

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 65-245aa

Immunogen: cyclin D1

Isotype: IgG2a

Information d'application

Indications d'application: WB: 1:2000-1:10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur Cyclin D1

Antigène: Cyclin D1 (CCND1)

Autre désignation: CCND1

Sujet:

Synonyms: G1/S-specific cyclin-D1|B-cell lymphoma 1 protein (BCL-1)|BCL-1 oncogene|PRAD1 oncogene|CCND1|BCL1|PRAD1

Background: CCND1(cyclin D1), also known as PRAD1 or BCL1, belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. CCND1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. The CCND1 gene, located on 11q13 has been reported to be overexpressed in mantle cell lymphoma(MCL) due to the chromosomal translocation. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Over-expression of CCND1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis.

Poids moléculaire: 36 kDa

ID gène: 595

UniProt: P24385

Pathways: Signalisation PI3K-Akt, Cycle Cellulaire, Mitotic G1-G1/S Phases, ER-Nucleus Signaling